Harry Gugger studied architecture after an apprenticeship as a toolmaker and stopped studies in machine engineering and German literature. From 1984 to 1989 he studied at the ETH Zürich with Flora Ruchat and at the Columbia University in New York with Tadao Ando. 1990 began his collaboration with Jacques Herzog and Pierre de Meuron. As a partner, he helped to develop Herzog & de Meuron from a small office to a global company.
Among many other projects, he was in charge of: Signal boxes I and II (1991-1994 / 1995-1999) and Engine Depot (1991-1995) in Basel; Library of the University Eberswalde (1994-1999); Tate Modern in London (1995-2000); Schaulager Basel for the Laurenz Foundation (1998-2003); Caixa Forum, Madrid (2001–2008) and the Laban Dance Centre in London (1998-2003), which was awarded the RIBA Stirling Prize 2003. In 2004 Harry Gugger received the Swiss Art Award Prix Meret Oppenheim.